Searchable abstracts of presentations at key conferences in endocrinology

ea0073oc3.4 | Oral Communications 3: Pituitary and Neuroendocrinology | ECE2021

Truncated somatostatin receptor variant SST5TMD4 determines somatostatin analogs response in corticotropinomas

Alejandro Ibáñez-Costa , Vázquez-Borrego Mari C. , Moreno-Moreno Paloma , Fuentes-Fayos Antonio C. , Moreno Eva Venegas , Fuentes-Fayos Juan Antonio , Herrera-Martínez Aura D. , Gahete Ortiz Manuel , Soto-Moreno Alfonso , Gálvez-Moreno Ángeles María , Luque Raul M. , Castaño Justo P.

IntroductionCushing’s disease is the result of prolonged exposure to excess cortisol caused by a pituitary tumor, known as corticotropinoma, which hypersecretes adrenocorticotropin (ACTH). Treatment with somatostatin analogs (SSA) has been shown to reduce hormone secretion and, to a lower extent, tumor growth in some subtypes of pituitary tumors, such as growth hormone secreting tumors. However, SSA are commonly ineffective in corticotropinomas. Pre...